Chemically Defined, High-Density Insect Cell-Based Expression System for Scalable AAV Vector Production

The recombinant adeno-associated virus (AAV) vector is one of the most utilized viral vectors in gene therapy due to its robust, long-term in vivo transgene expression and low toxicity. One major hurdle for clinical AAV applications is large-scale manufacturing. In this regard, the baculovirus-based...

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Detalles Bibliográficos
Autores principales: Kurasawa, James H., Park, Andrew, Sowers, Carrie R., Halpin, Rebecca A., Tovchigrechko, Andrey, Dobson, Claire L., Schmelzer, Albert E., Gao, Changshou, Wilson, Susan D., Ikeda, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591331/
https://www.ncbi.nlm.nih.gov/pubmed/33145369
http://dx.doi.org/10.1016/j.omtm.2020.09.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591331/
https://www.ncbi.nlm.nih.gov/pubmed/33145369
http://dx.doi.org/10.1016/j.omtm.2020.09.018

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