Macrophage migration inhibitory factor is regulated by HIF-1α and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner

ABSTRACT: Progressive cyst growth leads to decline of renal function in polycystic kidney disease. Macrophage migration inhibitory factor (MIF) was found to be upregulated in cyst-lining cells in a mouse model of polycystic kidney disease and to promote cyst growth. In addition, MIF can be secreted...

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Detalles Bibliográficos
Autores principales: Safi, Wajima, Kraus, Andre, Grampp, Steffen, Schödel, Johannes, Buchholz, Bjoern
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591438/
https://www.ncbi.nlm.nih.gov/pubmed/32885302
http://dx.doi.org/10.1007/s00109-020-01964-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591438/
https://www.ncbi.nlm.nih.gov/pubmed/32885302
http://dx.doi.org/10.1007/s00109-020-01964-1

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