The anti-malarial drug atovaquone potentiates platinum-mediated cancer cell death by increasing oxidative stress

Platinum chemotherapies are highly effective cytotoxic agents but often induce resistance when used as monotherapies. Combinatorial strategies limit this risk and provide effective treatment options for many cancers. Here, we repurpose atovaquone (ATQ), a well-tolerated & FDA-approved anti-malar...

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Detalles Bibliográficos
Autores principales: Coates, James T. T., Rodriguez-Berriguete, Gonzalo, Puliyadi, Rathi, Ashton, Thomas, Prevo, Remko, Wing, Archie, Granata, Giovanna, Pirovano, Giacomo, McKenna, Gillies W., Higgins, Geoff S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591508/
https://www.ncbi.nlm.nih.gov/pubmed/33133645
http://dx.doi.org/10.1038/s41420-020-00343-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591508/
https://www.ncbi.nlm.nih.gov/pubmed/33133645
http://dx.doi.org/10.1038/s41420-020-00343-6

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