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Differential involvement of caspase-6 in amyloid-β-induced fragmentation of lamin A and B

Amyloid-β (Aβ), a peptide implicated in Alzheimer's disease, was shown to cause specific fragmentation of lamin proteins, which was mediated by an unidentified protease named nuclear scaffold protease (NSP) independently of caspase-6. Because caspase-6 is responsible for the fragmentation proce...

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Detalles Bibliográficos
Autores principales: Islam, Md Imamul, Hossain, Md Selim, Park, Il-Seon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591731/
https://www.ncbi.nlm.nih.gov/pubmed/33145443
http://dx.doi.org/10.1016/j.bbrep.2020.100839