Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice

Medium-chain triglycerides (MCT), containing C(8)–C(12) fatty acids, are used to treat several pediatric disorders and are widely consumed as a nutritional supplement. Here, we investigated the role of the sirtuin deacylase Sirt5 in MCT metabolism by feeding Sirt5 knockout mice (Sirt5KO) high-fat di...

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Detalles Bibliográficos
Autores principales: Goetzman, Eric S., Bharathi, Sivakama S., Zhang, Yuxun, Zhao, Xue-Jun, Dobrowolski, Steven F., Peasley, Kevin, Sims-Lucas, Sunder, Monga, Satdarshan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591893/
https://www.ncbi.nlm.nih.gov/pubmed/33110171
http://dx.doi.org/10.1038/s41598-020-75615-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591893/
https://www.ncbi.nlm.nih.gov/pubmed/33110171
http://dx.doi.org/10.1038/s41598-020-75615-3

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