Structural modeling of GSK3β implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs

Glycogen synthase kinase-3β (GSK3β) controls many physiological pathways, and is implicated in many diseases including Alzheimer’s and several cancers. GSK3β-mediated phosphorylation of target residues in microtubule-associated protein tau (MAPTAU) contributes to MAPTAU hyperphosphorylation and subs...

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Detalles Bibliográficos
Autores principales: Balasubramaniam, Meenakshisundaram, Mainali, Nirjal, Bowroju, Suresh Kuarm, Atluri, Paavan, Penthala, Narsimha Reddy, Ayyadevera, Srinivas, Crooks, Peter A., Shmookler Reis, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591898/
https://www.ncbi.nlm.nih.gov/pubmed/33110096
http://dx.doi.org/10.1038/s41598-020-75020-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591898/
https://www.ncbi.nlm.nih.gov/pubmed/33110096
http://dx.doi.org/10.1038/s41598-020-75020-w

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