Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation

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SARS-CoV-2 is a betacoronavirus virus responsible for the COVID-19 pandemic. Here, we determine the X-ray crystal structure of a potent neutralizing monoclonal antibody, CV30, isolated from a patient infected with SARS-CoV-2, in complex with the receptor binding domain. The structure reveals that CV...

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Detalles Bibliográficos
Autores principales: Hurlburt, Nicholas K., Seydoux, Emilie, Wan, Yu-Hsin, Edara, Venkata Viswanadh, Stuart, Andrew B., Feng, Junli, Suthar, Mehul S., McGuire, Andrew T., Stamatatos, Leonidas, Pancera, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591918/
https://www.ncbi.nlm.nih.gov/pubmed/33110068
http://dx.doi.org/10.1038/s41467-020-19231-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591918/
https://www.ncbi.nlm.nih.gov/pubmed/33110068
http://dx.doi.org/10.1038/s41467-020-19231-9

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