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NKCC-1 mediated Cl(−) uptake in immature CA3 pyramidal neurons is sufficient to compensate phasic GABAergic inputs
Activation of GABA(A) receptors causes in immature neurons a functionally relevant decrease in the intracellular Cl(−) concentration ([Cl(−)](i)), a process termed ionic plasticity. Amount and duration of ionic plasticity depends on kinetic properties of [Cl(−)](i) homeostasis. In order to character...
Autores principales: | Kolbaev, Sergey N., Mohapatra, Namrata, Chen, Rongqing, Lombardi, Aniello, Staiger, Jochen F., Luhmann, Heiko J., Jedlicka, Peter, Kilb, Werner |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591924/ https://www.ncbi.nlm.nih.gov/pubmed/33110147 http://dx.doi.org/10.1038/s41598-020-75382-1 |
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