Overcoming primary and acquired resistance to anti-PD-L1 therapy by induction and activation of tumor-residing cDC1s

The ability of cancer cells to ensure T-cell exclusion from the tumor microenvironment is a significant mechanism of resistance to anti-PD-1/PD-L1 therapy. Evidence indicates crucial roles of Batf3-dependent conventional type-1 dendritic cells (cDC1s) for inducing antitumor T-cell immunity; however,...

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Detalles Bibliográficos
Autores principales: Oba, Takaaki, Long, Mark D., Keler, Tibor, Marsh, Henry C., Minderman, Hans, Abrams, Scott I., Liu, Song, Ito, Fumito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592056/
https://www.ncbi.nlm.nih.gov/pubmed/33110069
http://dx.doi.org/10.1038/s41467-020-19192-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592056/
https://www.ncbi.nlm.nih.gov/pubmed/33110069
http://dx.doi.org/10.1038/s41467-020-19192-z

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