Annotation of Allosteric Compounds to Enhance Bioactivity Modeling for Class A GPCRs

[Image: see text] Proteins often have both orthosteric and allosteric binding sites. Endogenous ligands, such as hormones and neurotransmitters, bind to the orthosteric site, while synthetic ligands may bind to orthosteric or allosteric sites, which has become a focal point in drug discovery. Usuall...

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Detalles Bibliográficos
Autores principales: Burggraaff, Lindsey, van Veen, Amber, Lam, Chi Chung, van Vlijmen, Herman W. T., IJzerman, Adriaan P., van Westen, Gerard J. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592116/
https://www.ncbi.nlm.nih.gov/pubmed/32931270
http://dx.doi.org/10.1021/acs.jcim.0c00695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592116/
https://www.ncbi.nlm.nih.gov/pubmed/32931270
http://dx.doi.org/10.1021/acs.jcim.0c00695

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