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Annotation of Allosteric Compounds to Enhance Bioactivity Modeling for Class A GPCRs
[Image: see text] Proteins often have both orthosteric and allosteric binding sites. Endogenous ligands, such as hormones and neurotransmitters, bind to the orthosteric site, while synthetic ligands may bind to orthosteric or allosteric sites, which has become a focal point in drug discovery. Usuall...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592116/ https://www.ncbi.nlm.nih.gov/pubmed/32931270 http://dx.doi.org/10.1021/acs.jcim.0c00695 |