Beyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display libraries

The early phase of protein drug development has traditionally focused on target binding properties leading to a desired mode of therapeutic action. As more protein therapeutics pass through the development pipeline; however, it is clear that non-optimal biophysical properties can emerge, particularl...

Descripción completa

Detalles Bibliográficos
Autores principales: Dyson, Michael R., Masters, Edward, Pazeraitis, Deividas, Perera, Rajika L., Syrjanen, Johanna L., Surade, Sachin, Thorsteinson, Nels, Parthiban, Kothai, Jones, Philip C., Sattar, Maheen, Wozniak-Knopp, Gordana, Rueker, Florian, Leah, Rachael, McCafferty, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592150/
https://www.ncbi.nlm.nih.gov/pubmed/33103593
http://dx.doi.org/10.1080/19420862.2020.1829335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592150/
https://www.ncbi.nlm.nih.gov/pubmed/33103593
http://dx.doi.org/10.1080/19420862.2020.1829335

Ejemplares similares