Endogenous HLA-DQ8αβ programs superantigens (SEG/SEI) to silence toxicity and unleash a tumoricidal network with long-term melanoma survival

BACKGROUND: As the most powerful T cell agonists known, superantigens (SAgs) have enormous potential for cancer immunotherapy. Their development has languished due to high incidence (60%–80%) of seroreactive neutralizing antibodies in humans and tumor necrosis factor-α (TNFα)-mediated cardiopulmonar...

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Detalles Bibliográficos
Autores principales: Knopick, Peter, Terman, David, Riha, Nathan, Alvine, Travis, Larson, Riley, Badiou, Cedric, Lina, Gerard, Ballantyne, John, Bradley, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592263/
https://www.ncbi.nlm.nih.gov/pubmed/33109631
http://dx.doi.org/10.1136/jitc-2020-001493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592263/
https://www.ncbi.nlm.nih.gov/pubmed/33109631
http://dx.doi.org/10.1136/jitc-2020-001493

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