Cargando…

Endogenous HLA-DQ8αβ programs superantigens (SEG/SEI) to silence toxicity and unleash a tumoricidal network with long-term melanoma survival

BACKGROUND: As the most powerful T cell agonists known, superantigens (SAgs) have enormous potential for cancer immunotherapy. Their development has languished due to high incidence (60%–80%) of seroreactive neutralizing antibodies in humans and tumor necrosis factor-α (TNFα)-mediated cardiopulmonar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Knopick, Peter, Terman, David, Riha, Nathan, Alvine, Travis, Larson, Riley, Badiou, Cedric, Lina, Gerard, Ballantyne, John, Bradley, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592263/ https://www.ncbi.nlm.nih.gov/pubmed/33109631 http://dx.doi.org/10.1136/jitc-2020-001493

Ejemplares similares

Sickle Cells Abolish Melanoma Tumorigenesis in Hemoglobin SS Knockin Mice and Augment the Tumoricidal Effect of Oncolytic Virus In Vivo
por: Sun, Chiang Wang, et al.
Publicado: (2016)

The incidence of HLA-DQ2/DQ8 in Turkish children with celiac disease and a comparison of the geographical distribution of HLA-DQ
por: Basturk, Ahmet, et al.
Publicado: (2017)

HLA-DQ2 and -DQ8 genotype frequency in Syrian celiac disease children: HLA-DQ relative risks evaluation
por: Murad, Hossam, et al.
Publicado: (2018)

Highly Sensitive and Specific Detection of Staphylococcal Enterotoxins SEA, SEG, SEH, and SEI by Immunoassay
por: Féraudet Tarisse, Cécile, et al.
Publicado: (2021)

HLA-DQ-Specific Recombinant Human Monoclonal Antibodies Allow for In-Depth Analysis of HLA-DQ Epitopes
por: Bezstarosti, Suzanne, et al.
Publicado: (2022)

Assessing the Prevalence of HLA-DQ2 and HLA-DQ8 in Lipedema Patients and the Potential Benefits of a Gluten-Free Diet
por: Amato, Alexandre C, et al.
Publicado: (2023)

THE PREVALENCE OF HLA DQ2 AND DQ8 IN PATIENTS WITH CELIAC DISEASE, IN FAMILY AND IN GENERAL POPULATION
por: CECILIO, Lucila Arantes, et al.
Publicado: (2015)

Meta-Analysis and Systematic Review of HLA DQ2/DQ8 in Adults with Celiac Disease
por: Aboulaghras, Sara, et al.
Publicado: (2023)

Polymorphic DQ alpha and DQ beta interactions dictate HLA class II determinants of allo-recognition
Publicado: (1990)

Evaluation of HLA-DQ2/DQ8 genotype in patients with celiac disease hospitalised in 2012 at the Department of Paediatrics
por: Szałowska-Woźniak, Dorota A., et al.
Publicado: (2014)

Human Leukocyte Antigen DQ (HLA‐DQ) genotypes and haplotypes and their association with phenotype in patients with celiac disease in India
por: Ramakrishna, Balakrishnan S, et al.
Publicado: (2021)

Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity
por: Kalim, Khalid W, et al.
Publicado: (2022)

Peptide binding predictions for HLA DR, DP and DQ molecules
por: Wang, Peng, et al.
Publicado: (2010)

Association of HLA-DR/DQ polymorphisms with schizophrenia in Tunisian patients
por: Sayeh, Aicha, et al.
Publicado: (2014)

HLA-DQ: Celiac disease vs inflammatory bowel disease
por: Bosca-Watts, Marta Maia, et al.
Publicado: (2018)

Immunogenetic Study of Diabetes Mellitus in Relation to HLA DQ and DR
por: Singh, Gyanendra, et al.
Publicado: (2020)

HLA-DQ antibodies in alloimmunity, what makes them different?
por: Meneghini, Maria, et al.
Publicado: (2023)

Fequency distribution of HLA DQ2 and DQ8 in celiac patients and first-degree relatives in Recife, northeastern Brazil
por: Castro-Antunes, Margarida Maria, et al.
Publicado: (2011)

HLA-DQ2 and -DQ8 haplotypes frequency and diagnostic utility in celiac disease patients of Gaza strip, Palestine
por: Ayesh, Basim M., et al.
Publicado: (2017)

Frequency of celiac disease and distribution of HLA-DQ2/DQ8 haplotypes among siblings of children with celiac disease
por: Sahin, Yasin, et al.
Publicado: (2022)

A review of the long-term use of proton pump inhibitors and risk of celiac disease in the context of HLA-DQ2 and HLA-DQ8 genetic predisposition
por: McMillan, Alexandra, et al.
Publicado: (2023)

Staphylococcal Enterotoxin Gene Cluster: Prediction of Enterotoxin (SEG and SEI) Production and of the Source of Food Poisoning on the Basis of vSaβ Typing
por: Schwendimann, L., et al.
Publicado: (2021)

HLA‐DR/DQ molecular mismatch: A prognostic biomarker for primary alloimmunity
por: Wiebe, Chris, et al.
Publicado: (2018)

The frequency of HLA-DQ2/DQ8 haplotypes and celiac disease among the first-degree relatives of patients with celiac disease
por: Mansouri, Masoume, et al.
Publicado: (2021)

Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients
por: Kovalchuka, Lilija, et al.
Publicado: (2012)

Peptide presentation by HLA-DQ molecules is associated with the development of immune tolerance
por: Manczinger, Máté, et al.
Publicado: (2018)

Frequency of HLA‐DQ, susceptibility genotypes for celiac disease, in Brazilian newborns
por: Almeida, Fernanda C., et al.
Publicado: (2018)

Distribution of HLA‐DQ risk genotypes for celiac disease in Ethiopian children
por: Gudeta, Adugna N., et al.
Publicado: (2020)

Development of an immunogenicity score for HLA‐DQ eplets: A conceptual study
por: Schawalder, Lara, et al.
Publicado: (2020)

Mice expressing HLA-DQ6α8β transgenes develop polychondritis spontaneously
por: Lamoureux, Jennifer L, et al.
Publicado: (2006)

TGFβ receptor inhibition unleashes interferon-β production by tumor-associated macrophages and enhances radiotherapy efficacy
por: Hamon, Pauline, et al.
Publicado: (2022)

Dual TLR9 and PD-L1 targeting unleashes dendritic cells to induce durable antitumor immunity
por: Fernandez-Rodriguez, Laura, et al.
Publicado: (2023)

Different binding motifs of the celiac disease-associated HLA molecules DQ2.5, DQ2.2, and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires
por: Bergseng, Elin, et al.
Publicado: (2014)

HLA-DR and HLA-DQ alleles in patients from the south of Brazil: markers for leprosy susceptibility and resistance
por: da Silva, Samira A, et al.
Publicado: (2009)

Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ
por: Hrdinová, Johana, et al.
Publicado: (2018)

Human leukocyte antigen (HLA)-DQ2 and -DQ8 haplotypes in celiac, celiac with type 1 diabetic, and celiac suspected pediatric cases
por: Siddiqui, Komal, et al.
Publicado: (2021)

Motifs of Three HLA-DQ Amino Acid Residues (α44, β57, β135) Capture Full Association With the Risk of Type 1 Diabetes in DQ2 and DQ8 Children
por: Zhao, Lue Ping, et al.
Publicado: (2020)

DNA methylation dysregulates and silences the HLA-DQ locus by altering chromatin architecture
por: Majumder, Parimal, et al.
Publicado: (2011)

HLA-DQ restricted activation of nitroso-sulfamethoxazole-specific CD4+ T-lymphocytes
por: Ogese, Monday, et al.
Publicado: (2014)

Relationship between HLA-DQ Gene Polymorphism and Hepatitis B Virus Infection
por: Xu, Tao, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_r9spoos27lrsot7a24ssait561