The natural compound obtusaquinone targets pediatric high-grade gliomas through ROS-mediated ER stress

BACKGROUND: Pediatric high-grade gliomas (pHGGs) are aggressive primary brain tumors with local invasive growth and poor clinical prognosis. Treatment of pHGGs is particularly challenging given the intrinsic resistance to chemotherapy, an absence of novel therapeutics, and the difficulty of drugs to...

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Detalles Bibliográficos
Autores principales: Teng, Jian, Lashgari, Ghazal, Tabet, Elie I, Tannous, Bakhos A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592425/
https://www.ncbi.nlm.nih.gov/pubmed/33134921
http://dx.doi.org/10.1093/noajnl/vdaa106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592425/
https://www.ncbi.nlm.nih.gov/pubmed/33134921
http://dx.doi.org/10.1093/noajnl/vdaa106

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