Cargando…

The natural compound obtusaquinone targets pediatric high-grade gliomas through ROS-mediated ER stress

BACKGROUND: Pediatric high-grade gliomas (pHGGs) are aggressive primary brain tumors with local invasive growth and poor clinical prognosis. Treatment of pHGGs is particularly challenging given the intrinsic resistance to chemotherapy, an absence of novel therapeutics, and the difficulty of drugs to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Teng, Jian, Lashgari, Ghazal, Tabet, Elie I, Tannous, Bakhos A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592425/ https://www.ncbi.nlm.nih.gov/pubmed/33134921 http://dx.doi.org/10.1093/noajnl/vdaa106

Ejemplares similares

High-throughput microRNA profiling of pediatric high-grade gliomas
por: Miele, Evelina, et al.
Publicado: (2014)

An affinity for brainstem microglia in pediatric high-grade gliomas of brainstem origin
por: Zats, Liat Peretz, et al.
Publicado: (2022)

Pediatric high-grade gliomas and the WHO CNS Tumor Classification—Perspectives of pediatric neuro-oncologists and neuropathologists in light of recent updates
por: Gielen, Gerrit H, et al.
Publicado: (2022)

Transitioning to molecular diagnostics in pediatric high-grade glioma: experiences with the 2016 WHO classification of CNS tumors
por: Baugh, Joshua N, et al.
Publicado: (2021)

Multicellular “hotspots” harbor high-grade potential in lower-grade gliomas
por: Kirby, Alastair J, et al.
Publicado: (2021)

Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patients
por: Izquierdo, Elisa, et al.
Publicado: (2021)

Establishment of patient-derived organoid models of lower-grade glioma
por: Abdullah, Kalil G, et al.
Publicado: (2021)

MR-guided focused ultrasound increases antibody delivery to nonenhancing high-grade glioma
por: Brighi, Caterina, et al.
Publicado: (2020)

Parents’ experiences of postmortem tumor donation for high-grade gliomas: benefits and suggested improvements
por: Robertson, Eden G, et al.
Publicado: (2021)

Combined molecular subtyping, grading, and segmentation of glioma using multi-task deep learning
por: van der Voort, Sebastian R, et al.
Publicado: (2022)

Imaging Tumor Vascularity and Response to Anti-Angiogenic Therapy Using Gaussia Luciferase
por: Kantar, Rami S., et al.
Publicado: (2016)

IDH mutation status is associated with distinct vascular gene expression signatures in lower-grade gliomas
por: Zhang, Lei, et al.
Publicado: (2018)

Structural gray matter alterations in glioblastoma and high-grade glioma—A potential biomarker of survival
por: Lamichhane, Bidhan, et al.
Publicado: (2023)

Outcomes after combined use of intraoperative MRI and 5-aminolevulinic acid in high-grade glioma surgery
por: Schatlo, Bawarjan, et al.
Publicado: (2015)

Tumor mutational burden predicts survival in patients with low-grade gliomas expressing mutated IDH1
por: Alghamri, Mahmoud S, et al.
Publicado: (2020)

Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis
por: Muskens, Ivo S, et al.
Publicado: (2020)

Generation of immunocompetent syngeneic allograft mouse models for pediatric diffuse midline glioma
por: du Chatinier, Aimée, et al.
Publicado: (2022)

Deep proteome investigation of high-grade gliomas reveals heterogeneity driving differential metabolism of 5-aminolevulinic acid
por: Ghantasala, Saicharan, et al.
Publicado: (2023)

Inhibition of microglial EZH2 leads to anti-tumoral effects in pediatric diffuse midline gliomas
por: Keane, Lily, et al.
Publicado: (2021)

Prospective prediction of clinical drug response in high-grade gliomas using an ex vivo 3D cell culture assay
por: Shuford, Stephen, et al.
Publicado: (2021)

Immune deconvolution and temporal mapping identifies stromal targets and developmental intervals for abrogating murine low-grade optic glioma formation
por: de Andrade Costa, Amanda, et al.
Publicado: (2021)

Glycolytic expression in lower-grade glioma reveals an epigenetic association between IDH mutation status and PDL1/2 expression
por: Givechian, Kevin B, et al.
Publicado: (2020)

Glioma-associated microglia/macrophages augment tumorigenicity in canine astrocytoma, a naturally occurring model of human glioma
por: Toedebusch, Ryan, et al.
Publicado: (2021)

Early-onset grade 2-3 diffuse gliomas and schwannomas increase the risk of central nervous system tumors among the patients’ relatives
por: Alanen, Eljas, et al.
Publicado: (2023)

Integrated longitudinal analysis of adult grade 4 diffuse gliomas with long-term relapse interval revealed upregulation of TGF-β signaling in recurrent tumors
por: Kashani, Elham, et al.
Publicado: (2022)

BSCI-04. Tumor-educated platelets promote breast cancer brain metastasis and therapeutic resistance
por: Tabet, Elie, et al.
Publicado: (2021)

Serial MR diffusion to predict treatment response in high-grade pediatric brain tumors: a comparison of regional and voxel-based diffusion change metrics
por: Rodriguez Gutierrez, Daniel, et al.
Publicado: (2013)

Long-lived tumor-associated macrophages in glioma
por: Georgieva, Petya B, et al.
Publicado: (2020)

Spatial concordance of DNA methylation classification in diffuse glioma
por: Verburg, Niels, et al.
Publicado: (2021)

Environmental and sex-specific molecular signatures of glioma causation
por: Claus, Elizabeth B, et al.
Publicado: (2021)

Receptor-driven invasion profiles in diffuse intrinsic pontine glioma
por: Karki, Anju, et al.
Publicado: (2021)

Distinct metabolic hallmarks of WHO classified adult glioma subtypes
por: Björkblom, Benny, et al.
Publicado: (2022)

Significance of molecular diagnostics for therapeutic decision-making in recurrent glioma
por: Blobner, Jens, et al.
Publicado: (2023)

Osteopontin regulates human glioma cell invasiveness and tumor growth in mice
por: Jan, Hsun-Jin, et al.
Publicado: (2010)

Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells
por: Lin, Hua, et al.
Publicado: (2017)

Rapid intraoperative molecular genetic classification of gliomas using Raman spectroscopy
por: Livermore, Laurent James, et al.
Publicado: (2019)

Akaluc bioluminescence offers superior sensitivity to track in vivo glioma expansion
por: Bozec, Dominique, et al.
Publicado: (2020)

Comparative evaluation of T-cell receptors in experimental glioma-draining lymph nodes
por: Blobner, Jens, et al.
Publicado: (2021)

MR1 overexpression correlates with poor clinical prognosis in glioma patients
por: Kubica, Phillip, et al.
Publicado: (2021)

Tumor-related molecular determinants of neurocognitive deficits in patients with diffuse glioma
por: van Kessel, Emma, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_veo1uqmfqp9dik3535nipgrefu