Cargando…

Amyloidogenic Nanoplaques in Cerebrospinal Fluid: Relationship to Amyloid Brain Uptake and Clinical Alzheimer’s Disease in a Memory Clinic Cohort

BACKGROUND: Aggregation of amyloid-β (Aβ) is an early pathological event in Alzheimer’s disease (AD). Consequently, measures of pathogenic aggregated Aβ are attractive biomarkers for AD. Here, we use a recently developed Thioflavin-T-Fluorescence Correlation Spectroscopy (ThT-FCS) assay to quantify...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aksnes, Mari, Müller, Ebba Glersen, Tiiman, Ann, Edwin, Trine Holt, Terenius, Lars, Revheim, Mona-Elisabeth, Vukojević, Vladana, Bogdanović, Nenad, Knapskog, Anne-Brita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592690/ https://www.ncbi.nlm.nih.gov/pubmed/32741818 http://dx.doi.org/10.3233/JAD-200237

Ejemplares similares

Comparison of Cerebrospinal Fluid Amyloidogenic Nanoplaques With Core Biomarkers of Alzheimer’s Disease
por: Aksnes, Mari, et al.
Publicado: (2021)

Associations of cerebrospinal fluid amyloidogenic nanoplaques with cytokines in Alzheimer’s disease
por: Aksnes, Mari, et al.
Publicado: (2021)

Serum Amyloidogenic Nanoplaques and Cytokines in Alzheimer’s Disease: Pilot Study in a Small Naturalistic Memory Clinic Cohort
por: Aksnes, Mari, et al.
Publicado: (2022)

Amyloidogenic Nanoplaques in Blood Serum of Patients with Alzheimer’s Disease Revealed by Time-Resolved Thioflavin T Fluorescence Intensity Fluctuation Analysis
por: Tiiman, Ann, et al.
Publicado: (2019)

Amyloid-β PET—Correlation with cerebrospinal fluid biomarkers and prediction of Alzheimer´s disease diagnosis in a memory clinic
por: Müller, Ebba Gløersen, et al.
Publicado: (2019)

Is Amyloid Burden Measured by (18)F-Flutemetamol PET Associated with Progression in Clinical Alzheimer’s Disease?
por: Müller, Ebba Gløersen, et al.
Publicado: (2022)

The interwoven fibril-like structure of amyloid-beta plaques in mouse brain tissue visualized using super-resolution STED microscopy
por: Johansson, Björn, et al.
Publicado: (2023)

Small Molecule Decoys of Aggregation for Elimination of Aβ-Peptide Toxicity
por: Oasa, Sho, et al.
Publicado: (2023)

Mobility and associations with levels of cerebrospinal fluid amyloid β and tau in a memory clinic cohort
por: Tangen, Gro Gujord, et al.
Publicado: (2023)

Conformation‐specific antibodies against multiple amyloid protofibril species from a single amyloid immunogen
por: Bonito‐Oliva, Alessandra, et al.
Publicado: (2019)

Factors that influence the levels of cerebrospinal fluid biomarkers in memory clinic patients
por: Knapskog, Anne-Brita, et al.
Publicado: (2017)

A high cerebrospinal fluid soluble TREM2 level is associated with slow clinical progression of Alzheimer's disease
por: Edwin, Trine Holt, et al.
Publicado: (2020)

Iso-α-acids in Nonalcoholic and Alcoholic Beer Stimulate Growth of Neuron-like SH-SY5Y Cells and Neuroepithelial Stem Cells
por: Laurent, Agneta J., et al.
Publicado: (2021)

Diagnostic accuracy of brain age prediction in a memory clinic population and comparison with clinically available volumetric measures
por: Persson, Karin, et al.
Publicado: (2023)

Smallest Secondary Nucleation Competent Aβ Aggregates Probed by an ATP-Independent Molecular Chaperone Domain
por: Leppert, Axel, et al.
Publicado: (2021)

Sex-specific associations of matrix metalloproteinases in Alzheimer’s disease
por: Aksnes, Mari, et al.
Publicado: (2023)

Ethanol/Naltrexone Interactions at the mu-Opioid Receptor. CLSM/FCS Study in Live Cells
por: Vukojević, Vladana, et al.
Publicado: (2008)

Time from dementia diagnosis to nursing-home admission and death among persons with dementia: A multistate survival analysis
por: Mjørud, Marit, et al.
Publicado: (2020)

A strategy for designing allosteric modulators of transcription factor dimerization
por: Oasa, Sho, et al.
Publicado: (2020)

Cerebrospinal fluid sTREM2 in Alzheimer’s disease: comparisons between clinical presentation and AT classification
por: Knapskog, Anne-Brita, et al.
Publicado: (2020)

Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro
por: Ozawa, Daisaku, et al.
Publicado: (2016)

Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HT(1A)) Receptors Heterodimerization and Cellular Effectors (Ca(2+), ERK1/2 and p38) Activation
por: Radoi, Vlad, et al.
Publicado: (2022)

Cooperativity among Short Amyloid Stretches in Long Amyloidogenic Sequences
por: Hu, Lele, et al.
Publicado: (2012)

Effects of Intramolecular Distance between Amyloidogenic Domains on Amyloid Aggregation
por: Ko, Ahra, et al.
Publicado: (2012)

Mechanism of Amyloid Gel Formation by Several Short Amyloidogenic Peptides
por: Galzitskaya, Oxana V., et al.
Publicado: (2021)

Nanoscale Effects of Ethanol and Naltrexone on Protein Organization in the Plasma Membrane Studied by Photoactivated Localization Microscopy (PALM)
por: Tobin, Steven J., et al.
Publicado: (2014)

Control of Hox transcription factor concentration and cell-to-cell variability by an auto-regulatory switch
por: Papadopoulos, Dimitrios K., et al.
Publicado: (2019)

Mapping the Direction of Nucleocytoplasmic Transport of Glucocorticoid Receptor (GR) in Live Cells Using Two-Foci Cross-Correlation in Massively Parallel Fluorescence Correlation Spectroscopy (mpFCS)
por: Nikolić, Stanko N., et al.
Publicado: (2023)

Survival and years of life lost in various aetiologies of dementia, mild cognitive impairment (MCI) and subjective cognitive decline (SCD) in Norway
por: Strand, Bjørn Heine, et al.
Publicado: (2018)

Amyloidogenicity and toxicity of the reverse and scrambled variants of amyloid‐β 1‐42
por: Vadukul, Devkee M., et al.
Publicado: (2017)

Lack of N-glycosylation increases amyloidogenic processing of the amyloid precursor protein
por: Lin, Tong, et al.
Publicado: (2022)

Progression to dementia in memory clinic patients with mild cognitive impairment and normal β-amyloid
por: Rosenberg, Anna, et al.
Publicado: (2019)

Structural Similarities and Differences between Amyloidogenic and Non-Amyloidogenic Islet Amyloid Polypeptide (IAPP) Sequences and Implications for the Dual Physiological and Pathological Activities of These Peptides
por: Wu, Chun, et al.
Publicado: (2013)

Naltrexone blocks alcohol-induced effects on kappa-opioid receptors in the plasma membrane
por: Terenius, Lars, et al.
Publicado: (2023)

Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts
por: Ehehalt, Robert, et al.
Publicado: (2003)

SIRT3 activator Honokiol attenuates β-Amyloid by modulating amyloidogenic pathway
por: Ramesh, Sindhu, et al.
Publicado: (2018)

Cerebrospinal fluid catecholamines in Alzheimer’s disease patients with and without biological disease
por: Henjum, Kristi, et al.
Publicado: (2022)

Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity
por: Spitzer, Philipp, et al.
Publicado: (2016)

On the border of the amyloidogenic sequences: prefix analysis of the parallel beta sheets in the PDB_Amyloid collection
por: Takács, Kristóf, et al.
Publicado: (2021)

Structural characterisation of amyloid-like fibrils formed by an amyloidogenic peptide segment of β-lactoglobulin
por: Gowda, Vasantha, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_p8n9s6479rvpgces2ikqkb00tn