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Gradual compaction of the nascent peptide during cotranslational folding on the ribosome

Nascent polypeptides begin to fold in the constrained space of the ribosomal peptide exit tunnel. Here we use force-profile analysis (FPA) and photo-induced energy-transfer fluorescence correlation spectroscopy (PET-FCS) to show how a small α-helical domain, the N-terminal domain of HemK, folds cotr...

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Detalles Bibliográficos
Autores principales: Liutkute, Marija, Maiti, Manisankar, Samatova, Ekaterina, Enderlein, Jörg, Rodnina, Marina V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593090/
https://www.ncbi.nlm.nih.gov/pubmed/33112737
http://dx.doi.org/10.7554/eLife.60895