Tuning the Functionality by Splicing: Factor H and Its Alternative Splice Variant FHL-1 Share a Gene but Not All Functions

The alternative pathway regulator Factor H-like protein 1 (FHL-1) is composed of the first 7 N-terminal complement control protein domains of Factor H (FH) and protects host surfaces from uncontrolled complement attack. Although FHL-1 shares the N-terminal regulatory domains with FH, it was thought...

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Detalles Bibliográficos
Autores principales: Mannes, Marco, Dopler, Arthur, Huber-Lang, Markus, Schmidt, Christoph Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593401/
https://www.ncbi.nlm.nih.gov/pubmed/33178228
http://dx.doi.org/10.3389/fimmu.2020.596415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593401/
https://www.ncbi.nlm.nih.gov/pubmed/33178228
http://dx.doi.org/10.3389/fimmu.2020.596415

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