Novel antibody against low‐n oligomers of tau protein promotes clearance of tau in cells via lysosomes

INTRODUCTION: Tau, a natively unfolded soluble protein, forms abnormal oligomers and insoluble filaments in several neurodegenerative diseases, including Alzheimer disease (AD). Tau‐induced toxicity is mainly due to oligomers rather than monomers or fibrils. METHODS: We have developed monoclonal ant...

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Detalles Bibliográficos
Autores principales: Chandupatla, Ram Reddy, Flatley, Andrew, Feederle, Regina, Mandelkow, Eva‐Maria, Kaniyappan, Senthilvelrajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593557/
https://www.ncbi.nlm.nih.gov/pubmed/33145390
http://dx.doi.org/10.1002/trc2.12097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593557/
https://www.ncbi.nlm.nih.gov/pubmed/33145390
http://dx.doi.org/10.1002/trc2.12097

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