α(2)-Adrenergic Disruption of β Cell BDNF-TrkB Receptor Tyrosine Kinase Signaling

Adrenergic signaling is a well-known input into pancreatic islet function. Specifically, the insulin-secreting islet β cell expresses the G(i/o)-linked α(2)-adrenergic receptor, which upon activation suppresses insulin secretion. The use of the adrenergic agonist epinephrine at micromolar doses may...

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Detalles Bibliográficos
Autores principales: Kalwat, Michael A., Huang, Zhimin, Binns, Derk D., McGlynn, Kathleen, Cobb, Melanie H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593622/
https://www.ncbi.nlm.nih.gov/pubmed/33178692
http://dx.doi.org/10.3389/fcell.2020.576396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593622/
https://www.ncbi.nlm.nih.gov/pubmed/33178692
http://dx.doi.org/10.3389/fcell.2020.576396

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