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α(2)-Adrenergic Disruption of β Cell BDNF-TrkB Receptor Tyrosine Kinase Signaling
Adrenergic signaling is a well-known input into pancreatic islet function. Specifically, the insulin-secreting islet β cell expresses the G(i/o)-linked α(2)-adrenergic receptor, which upon activation suppresses insulin secretion. The use of the adrenergic agonist epinephrine at micromolar doses may...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593622/ https://www.ncbi.nlm.nih.gov/pubmed/33178692 http://dx.doi.org/10.3389/fcell.2020.576396 |