Discovery of N-(2-Amino-4-Fluorophenyl)-4-[bis-(2-Chloroethyl)-Amino]-Benzamide as a Potent HDAC3 Inhibitor

In discovery of HDAC inhibitors with improved activity and selectivity, fluorine substitution was performed on our previously derived lead compound. The synthesized molecules N-(2-amino-4-fluorophenyl)-4-[bis-(2-chloroethyl)-amino]-benzamide (FNA) exhibited class I (HDAC1, 2, and 3) selectivity in t...

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Detalles Bibliográficos
Autores principales: Chen, Yiming, Feng, Jinhong, Hu, Yajie, Wang, Xuejian, Song, Weiguo, Zhang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593677/
https://www.ncbi.nlm.nih.gov/pubmed/33178617
http://dx.doi.org/10.3389/fonc.2020.592385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593677/
https://www.ncbi.nlm.nih.gov/pubmed/33178617
http://dx.doi.org/10.3389/fonc.2020.592385

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