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In vivo Analysis of CRISPR/Cas9 Induced Atlastin Pathological Mutations in Drosophila

The endoplasmic reticulum (ER) is a highly dynamic network whose shape is thought to be actively regulated by membrane resident proteins. Mutation of several such morphology regulators cause the neurological disorder Hereditary Sp astic Paraplegia (HSP), suggesting a critical role of ER shape mainte...

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Detalles Bibliográficos
Autores principales: Montagna, Aldo, Vajente, Nicola, Pendin, Diana, Daga, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593789/
https://www.ncbi.nlm.nih.gov/pubmed/33177972
http://dx.doi.org/10.3389/fnins.2020.547746