Cargando…
Characterization of Asparagine Deamidation in Immunodominant Myelin Oligodendrocyte Glycoprotein Peptide Potential Immunotherapy for the Treatment of Multiple Sclerosis
Mannan (polysaccharide) conjugated with a myelin oligodendrocyte glycoprotein (MOG) peptide, namely (KG)(5)MOG(35–55), represents a potent and promising new approach for the immunotherapy of Multiple Sclerosis (MS). The MOG(35–55) epitope conjugated with the oxidized form of mannan (poly-mannose) vi...
Autores principales: | Androutsou, Maria-Eleni, Nteli, Agathi, Gkika, Areti, Avloniti, Maria, Dagkonaki, Anastasia, Probert, Lesley, Tselios, Theodore, Golič Grdadolnik, Simona |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593956/ https://www.ncbi.nlm.nih.gov/pubmed/33066323 http://dx.doi.org/10.3390/ijms21207566 |
Ejemplares similares
-
Maturation of circulating Ly6C(hi)CCR2(+) monocytes by mannan-MOG induces antigen-specific tolerance and reverses autoimmune encephalomyelitis
por: Dagkonaki, Anastasia, et al.
Publicado: (2022) -
A Cyclic Altered Peptide Analogue Based on Myelin Basic Protein 87–99 Provides Lasting Prophylactic and Therapeutic Protection Against Acute Experimental Autoimmune Encephalomyelitis
por: Emmanouil, Mary, et al.
Publicado: (2018) -
Mannan-MOG35-55 Reverses Experimental Autoimmune Encephalomyelitis, Inducing a Peripheral Type 2 Myeloid Response, Reducing CNS Inflammation, and Preserving Axons in Spinal Cord Lesions
por: Dagkonaki, Anastasia, et al.
Publicado: (2020) -
Implications of Metal Binding and Asparagine Deamidation for Amyloid Formation
por: Sadakane, Yutaka, et al.
Publicado: (2018) -
Structure Based Prediction of Asparagine Deamidation Propensity in Monoclonal Antibodies
por: Yan, Qingrong, et al.
Publicado: (2018)