A Systematic Evaluation of High-Throughput Sequencing Approaches to Identify Low-Frequency Single Nucleotide Variants in Viral Populations

High-throughput sequencing such as those provided by Illumina are an efficient way to understand sequence variation within viral populations. However, challenges exist in distinguishing process-introduced error from biological variance, which significantly impacts our ability to identify sub-consens...

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Detalles Bibliográficos
Autores principales: King, David J., Freimanis, Graham, Lasecka-Dykes, Lidia, Asfor, Amin, Ribeca, Paolo, Waters, Ryan, King, Donald P., Laing, Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594041/
https://www.ncbi.nlm.nih.gov/pubmed/33092085
http://dx.doi.org/10.3390/v12101187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594041/
https://www.ncbi.nlm.nih.gov/pubmed/33092085
http://dx.doi.org/10.3390/v12101187

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