Mechanochemical Synthesis and Structure of the Tetrahydrate and Mesoporous Anhydrous Metforminium(2+)-N,N′-1,4-Phenylenedioxalamic Acid (1:2) Salt: The Role of Hydrogen Bonding and n→π * Charge Assisted Interactions

A new organic salt of metformin, an antidiabetic drug, and N,N′-(1,4-phenylene)dioxalamic acid, was mechanochemically synthesized, purified by crystallization from solution and characterized by single X-ray crystallography. The structure revealed a salt-type crystal hydrate composed of one dicationi...

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Detalles Bibliográficos
Autores principales: Chong-Canto, Sayuri, García-Báez, Efrén V., Martínez-Martínez, Francisco J., Ramos-Organillo, Angel A., Padilla-Martínez, Itzia I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594043/
https://www.ncbi.nlm.nih.gov/pubmed/33096739
http://dx.doi.org/10.3390/pharmaceutics12100998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594043/
https://www.ncbi.nlm.nih.gov/pubmed/33096739
http://dx.doi.org/10.3390/pharmaceutics12100998

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