Discovery of Potential Chemical Probe as Inhibitors of CXCL12 Using Ligand-Based Virtual Screening and Molecular Dynamic Simulation

CXCL12 are small pro-inflammatory chemo-attractant cytokines that bind to a specific receptor CXCR4 with a role in angiogenesis, tumor progression, metastasis, and cell survival. Globally, cancer metastasis is a major cause of morbidity and mortality. In this study, we targeted CXCL12 rather than th...

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Detalles Bibliográficos
Autores principales: Haider, Sajjad, Barakat, Assem, Ul-Haq, Zaheer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594044/
https://www.ncbi.nlm.nih.gov/pubmed/33092204
http://dx.doi.org/10.3390/molecules25204829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594044/
https://www.ncbi.nlm.nih.gov/pubmed/33092204
http://dx.doi.org/10.3390/molecules25204829

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