A Comprehensive Proteomics Analysis of the JC Virus (JCV) Large and Small Tumor Antigen Interacting Proteins: Large T Primarily Targets the Host Protein Complexes with V-ATPase and Ubiquitin Ligase Activities While Small t Mostly Associates with Those Having Phosphatase and Chromatin-Remodeling Functions

The oncogenic potential of both the polyomavirus large (LT-Ag) and small (Sm t-Ag) tumor antigens has been previously demonstrated in both tissue culture and animal models. Even the contribution of the MCPyV tumor antigens to the development of an aggressive human skin cancer, Merkel cell carcinoma,...

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Detalles Bibliográficos
Autores principales: Saribas, Sami, Safak, Mahmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594058/
https://www.ncbi.nlm.nih.gov/pubmed/33092197
http://dx.doi.org/10.3390/v12101192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594058/
https://www.ncbi.nlm.nih.gov/pubmed/33092197
http://dx.doi.org/10.3390/v12101192

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