N-Alkylated Iminosugar Based Ligands: Synthesis and Inhibition of Human Lysosomal β-Glucocerebrosidase

The scope of a series of N-alkylated iminosugar based inhibitors in the d-gluco as well as d-xylo configuration towards their interaction with human lysosomal β-glucocerebrosidase has been evaluated. A versatile synthetic toolbox has been developed for the synthesis of N-alkylated iminosugar scaffol...

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Detalles Bibliográficos
Autores principales: Wolfsgruber, Andreas, Thonhofer, Martin, Weber, Patrick, Nasseri, Seyed A., Fischer, Roland, Schalli, Michael, Stütz, Arnold E., Withers, Stephen G., Wrodnigg, Tanja M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594070/
https://www.ncbi.nlm.nih.gov/pubmed/33050585
http://dx.doi.org/10.3390/molecules25204618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594070/
https://www.ncbi.nlm.nih.gov/pubmed/33050585
http://dx.doi.org/10.3390/molecules25204618

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