Synthesis, In Silico and In Vitro Assessment of New Quinazolinones as Anticancer Agents via Potential AKT Inhibition

A series of novel quinazolinone derivatives (2–13) was synthesized and examined for their cytotoxicity to HepG2, MCF-7, and Caco-2 in an MTT assay. Among these derivatives, compounds 4 and 9 exhibited significant cytotoxic activity against Caco-2, HepG2, and MCF-7 cancer cells. Compound 4 had more s...

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Detalles Bibliográficos
Autores principales: Noser, Ahmed A., El-Naggar, Mohamed, Donia, Thoria, Abdelmonsef, Aboubakr H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594071/
https://www.ncbi.nlm.nih.gov/pubmed/33080996
http://dx.doi.org/10.3390/molecules25204780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594071/
https://www.ncbi.nlm.nih.gov/pubmed/33080996
http://dx.doi.org/10.3390/molecules25204780

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