The majority of β-catenin mutations in colorectal cancer is homozygous

BACKGROUND: β-catenin activation plays a crucial role for tumourigenesis in the large intestine but except for Lynch syndrome (LS) associated cancers stabilizing mutations of β-catenin gene (CTNNB1) are rare in colorectal cancer (CRC). Previous animal studies provide an explanation for this observat...

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Detalles Bibliográficos
Autores principales: Arnold, Alexander, Tronser, Moritz, Sers, Christine, Ahadova, Ayel, Endris, Volker, Mamlouk, Soulafa, Horst, David, Möbs, Markus, Bischoff, Philip, Kloor, Michael, Bläker, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594410/
https://www.ncbi.nlm.nih.gov/pubmed/33115416
http://dx.doi.org/10.1186/s12885-020-07537-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594410/
https://www.ncbi.nlm.nih.gov/pubmed/33115416
http://dx.doi.org/10.1186/s12885-020-07537-2

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