Cargando…

The majority of β-catenin mutations in colorectal cancer is homozygous

BACKGROUND: β-catenin activation plays a crucial role for tumourigenesis in the large intestine but except for Lynch syndrome (LS) associated cancers stabilizing mutations of β-catenin gene (CTNNB1) are rare in colorectal cancer (CRC). Previous animal studies provide an explanation for this observat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arnold, Alexander, Tronser, Moritz, Sers, Christine, Ahadova, Ayel, Endris, Volker, Mamlouk, Soulafa, Horst, David, Möbs, Markus, Bischoff, Philip, Kloor, Michael, Bläker, Hendrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594410/ https://www.ncbi.nlm.nih.gov/pubmed/33115416 http://dx.doi.org/10.1186/s12885-020-07537-2

Ejemplares similares

Correction to: The majority of β-catenin mutations in colorectal cancer is homozygous
por: Arnold, Alexander, et al.
Publicado: (2020)

Malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression
por: Mamlouk, Soulafa, et al.
Publicado: (2020)

Mathematical modeling of multiple pathways in colorectal carcinogenesis using dynamical systems with Kronecker structure
por: Haupt, Saskia, et al.
Publicado: (2021)

DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer
por: Mamlouk, Soulafa, et al.
Publicado: (2017)

Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance
por: Morkel, Markus, et al.
Publicado: (2015)

Robust in-silico identification of Cancer Cell Lines based on RNA and targeted DNA sequencing data
por: Otto, Raik, et al.
Publicado: (2019)

Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe
por: Gastl, Bastian, et al.
Publicado: (2020)

Distinct Mutational Profile of Lynch Syndrome Colorectal Cancers Diagnosed under Regular Colonoscopy Surveillance
por: Ahadova, Aysel, et al.
Publicado: (2021)

Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer
por: Uhlitz, Florian, et al.
Publicado: (2021)

Mutations in POLE and survival of colorectal cancer patients – link to disease stage and treatment
por: Stenzinger, Albrecht, et al.
Publicado: (2014)

Implications of Hereditary Origin on the Immune Phenotype of Mismatch Repair-Deficient Cancers: Systematic Literature Review
por: Bohaumilitzky, Lena, et al.
Publicado: (2020)

External validation of molecular subtype classifications of colorectal cancer based on microsatellite instability, CIMP, BRAF and KRAS
por: Alwers, Elizabeth, et al.
Publicado: (2019)

No association of CpG island methylator phenotype and colorectal cancer survival: population-based study
por: Jia, Min, et al.
Publicado: (2016)

Beta-2-microglobulin Mutations Are Linked to a Distinct Metastatic Pattern and a Favorable Outcome in Microsatellite-Unstable Stage IV Gastrointestinal Cancers
por: Busch, Elena, et al.
Publicado: (2021)

Smoking, alcohol consumption and colorectal cancer risk by molecular pathological subtypes and pathways
por: Amitay, Efrat L., et al.
Publicado: (2020)

Uncoupling of EGFR–RAS signaling and nuclear localization of YBX1 in colorectal cancer
por: Roßner, F, et al.
Publicado: (2016)

High endothelial venules are associated with microsatellite instability, hereditary background and immune evasion in colorectal cancer
por: Pfuderer, Pauline L., et al.
Publicado: (2019)

Microsatellite instability in colorectal cancer is associated with local lymphocyte infiltration and low frequency of distant metastases
por: Buckowitz, A, et al.
Publicado: (2005)

A RAS-Independent Biomarker Panel to Reliably Predict Response to MEK Inhibition in Colorectal Cancer
por: Pfohl, Ulrike, et al.
Publicado: (2022)

Nachweis der BRAF-V600E-Mutation beim metastasierten kolorektalen Karzinom: Ein QuIP-Ringversuch
por: Jöhrens, Korinna, et al.
Publicado: (2021)

DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas and pancreatic neuroendocrine tumors
por: Simon, Tincy, et al.
Publicado: (2022)

No major tumorigenic role for β-catenin in serrated as opposed to conventional colorectal adenomas
por: Yamamoto, T, et al.
Publicado: (2003)

Differential Glycosite Profiling—A Versatile Method to Compare Membrane Glycoproteomes
por: Michalak, Malwina, et al.
Publicado: (2021)

Lynch syndrome cancer vaccines: A roadmap for the development of precision immunoprevention strategies
por: Sei, Shizuko, et al.
Publicado: (2023)

Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids
por: Riemer, Pamela, et al.
Publicado: (2017)

A prognostic CpG score derived from epigenome-wide profiling of tumor tissue was independently associated with colorectal cancer survival
por: Jia, Min, et al.
Publicado: (2019)

Treffen der AG Gastroenteropathologie am 10. Juni 2021: 105. jährliche Tagung der Deutschen Pathologischen Gesellschaft, Onlinekonferenz
por: Bläker, Hendrik
Publicado: (2021)

Treatment resistance analysis reveals GLUT‐1‐mediated glucose uptake as a major target of synthetic rocaglates in cancer cells
por: Sieber‐Frank, Julia, et al.
Publicado: (2021)

Mismatch Repair-Deficient Crypt Foci in Lynch Syndrome – Molecular Alterations and Association with Clinical Parameters
por: Staffa, Laura, et al.
Publicado: (2015)

Microsatellite instability and survival after adjuvant chemotherapy among stage II and III colon cancer patients: results from a population‐based study
por: Alwers, Elizabeth, et al.
Publicado: (2020)

Response to neoadjuvant treatment among rectal cancer patients in a population-based cohort
por: Alwers, Elizabeth, et al.
Publicado: (2020)

In vitro selection of oligonucleotides that bind double-stranded DNA in the presence of triplex-stabilizing agents
por: Ayel, Elodie, et al.
Publicado: (2010)

The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution
por: Ballhausen, Alexej, et al.
Publicado: (2020)

Complex pattern of immune evasion in MSI colorectal cancer
por: Ozcan, Mine, et al.
Publicado: (2018)

The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine
por: Schwartz, J. C., et al.
Publicado: (2018)

Outcome and prognostic factors in patients undergoing salvage therapy for recurrent esophagogastric cancer after multimodal treatment
por: Apostolidis, Leonidas, et al.
Publicado: (2022)

Homozygous familial hypercholesterolemia
por: Parihar, Ravi Kumar, et al.
Publicado: (2012)

Homozygous Familial Hypercholesterolemia
por: Nohara, Atsushi, et al.
Publicado: (2021)

Droplet Microarray Based on Superhydrophobic-Superhydrophilic Patterns for Single Cell Analysis
por: Jogia, Gabriella E., et al.
Publicado: (2016)

Novel Presentation of Homozygous Familial Hypercholesterolemia With Homozygous Variants in Both LDLR and APOB Genes
por: Derenbecker, Robert, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_gv69tbqprsfgmjo9q19p0bujqf