Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice

BACKGROUND: The neuronal ceroid lipofuscinoses (CLN diseases) are fatal lysosomal storage diseases causing neurodegeneration in the CNS. We have previously shown that neuroinflammation comprising innate and adaptive immune reactions drives axonal damage and neuron loss in the CNS of palmitoyl protei...

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Detalles Bibliográficos
Autores principales: Berve, Kristina, West, Brian L., Martini, Rudolf, Groh, Janos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594417/
https://www.ncbi.nlm.nih.gov/pubmed/33115477
http://dx.doi.org/10.1186/s12974-020-01996-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594417/
https://www.ncbi.nlm.nih.gov/pubmed/33115477
http://dx.doi.org/10.1186/s12974-020-01996-x

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