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Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice
BACKGROUND: The neuronal ceroid lipofuscinoses (CLN diseases) are fatal lysosomal storage diseases causing neurodegeneration in the CNS. We have previously shown that neuroinflammation comprising innate and adaptive immune reactions drives axonal damage and neuron loss in the CNS of palmitoyl protei...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594417/ https://www.ncbi.nlm.nih.gov/pubmed/33115477 http://dx.doi.org/10.1186/s12974-020-01996-x |