The proline-rich domain promotes Tau liquid–liquid phase separation in cells

Tau protein in vitro can undergo liquid–liquid phase separation (LLPS); however, observations of this phase transition in living cells are limited. To investigate protein state transitions in living cells, we attached Cry2 to Tau and studied the contribution of each domain that drives the Tau cluste...

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Detalles Bibliográficos
Autores principales: Zhang, Xuemei, Vigers, Michael, McCarty, James, Rauch, Jennifer N., Fredrickson, Glenn H., Wilson, Maxwell Z., Shea, Joan-Emma, Han, Songi, Kosik, Kenneth S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594490/
https://www.ncbi.nlm.nih.gov/pubmed/32997736
http://dx.doi.org/10.1083/jcb.202006054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594490/
https://www.ncbi.nlm.nih.gov/pubmed/32997736
http://dx.doi.org/10.1083/jcb.202006054

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