Loss of CBX2 induces genome instability and senescence-associated chromosomal rearrangements

The polycomb group protein CBX2 is an important epigenetic reader involved in cell proliferation and differentiation. While CBX2 overexpression occurs in a wide range of human tumors, targeted deletion results in homeotic transformation, proliferative defects, and premature senescence. However, its...

Descripción completa

Detalles Bibliográficos
Autores principales: Baumann, Claudia, Zhang, Xiangyu, De La Fuente, Rabindranath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594495/
https://www.ncbi.nlm.nih.gov/pubmed/32870972
http://dx.doi.org/10.1083/jcb.201910149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594495/
https://www.ncbi.nlm.nih.gov/pubmed/32870972
http://dx.doi.org/10.1083/jcb.201910149

Ejemplares similares