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Loss of CBX2 induces genome instability and senescence-associated chromosomal rearrangements
The polycomb group protein CBX2 is an important epigenetic reader involved in cell proliferation and differentiation. While CBX2 overexpression occurs in a wide range of human tumors, targeted deletion results in homeotic transformation, proliferative defects, and premature senescence. However, its...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594495/ https://www.ncbi.nlm.nih.gov/pubmed/32870972 http://dx.doi.org/10.1083/jcb.201910149 |