Synthesis and biological activity of 2-cyanoacrylamide derivatives tethered to imidazopyridine as TAK1 inhibitors

The importance of transforming growth factor beta-activated kinase 1 (TAK1) to cell survival has been demonstrated in many studies. TAK1 regulates signalling cascades, the NF-κB pathway and the mitogen-activated protein kinase (MAPK) pathway. TAK1 inhibitors can induce the apoptosis of cancerous cel...

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Detalles Bibliográficos
Autores principales: Kang, Seok Jong, Lee, Jung Wuk, Song, Jiho, Park, Jiwon, Choi, Jaeyul, Suh, Kwee Hyun, Min, Kyung Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594721/
https://www.ncbi.nlm.nih.gov/pubmed/33086897
http://dx.doi.org/10.1080/14756366.2020.1833876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594721/
https://www.ncbi.nlm.nih.gov/pubmed/33086897
http://dx.doi.org/10.1080/14756366.2020.1833876

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