Cargando…

Synthesis and biological activity of 2-cyanoacrylamide derivatives tethered to imidazopyridine as TAK1 inhibitors

The importance of transforming growth factor beta-activated kinase 1 (TAK1) to cell survival has been demonstrated in many studies. TAK1 regulates signalling cascades, the NF-κB pathway and the mitogen-activated protein kinase (MAPK) pathway. TAK1 inhibitors can induce the apoptosis of cancerous cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kang, Seok Jong, Lee, Jung Wuk, Song, Jiho, Park, Jiwon, Choi, Jaeyul, Suh, Kwee Hyun, Min, Kyung Hoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594721/ https://www.ncbi.nlm.nih.gov/pubmed/33086897 http://dx.doi.org/10.1080/14756366.2020.1833876

Ejemplares similares

Structure-activity relationship of 7-aryl-2-anilino-pyrrolopyrimidines as Mer and Axl tyrosine kinase inhibitors
por: Chung, Shin Hyuck, et al.
Publicado: (2020)

De Novo Design of Imidazopyridine-Tethered Pyrazolines That Target Phosphorylation of STAT3 in Human Breast Cancer Cells
por: Ravish, Akshay, et al.
Publicado: (2023)

Recent Developments in the Photochemical Synthesis of Functionalized Imidazopyridines
por: Tran, Christine, et al.
Publicado: (2022)

Substituted imidazopyridines as potent inhibitors of HCV replication()
por: Vliegen, Inge, et al.
Publicado: (2009)

Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists
por: Butera, Roberto, et al.
Publicado: (2021)

Synthesis of New Imidazopyridine Nucleoside Derivatives Designed as Maribavir Analogues
por: Papadakis, Georgios, et al.
Publicado: (2020)

Recent advances on the transition-metal-catalyzed synthesis of imidazopyridines: an updated coverage
por: Reen, Gagandeep Kour, et al.
Publicado: (2019)

Iodine-Catalyzed Multicomponent Synthesis of Highly Fluorescent Pyrimidine-Linked Imidazopyridines
por: Acharya, Swadhin Swaraj, et al.
Publicado: (2022)

Discovery of Novel Imidazopyridine GSK-3β Inhibitors Supported by Computational Approaches
por: Buonfiglio, Rosa, et al.
Publicado: (2020)

Design, synthesis and evaluation of 2, 6, 8-substituted Imidazopyridine derivatives as potent PI3Kα inhibitors
por: Chen, Rui, et al.
Publicado: (2023)

An Investigation of Molecular Docking and Molecular Dynamic Simulation on Imidazopyridines as B-Raf Kinase Inhibitors
por: Xie, Huiding, et al.
Publicado: (2015)

Imidazopyridines as Potent KDM5 Demethylase Inhibitors Promoting Reprogramming Efficiency of Human iPSCs
por: Dabiri, Yasamin, et al.
Publicado: (2019)

Imidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels
por: O'Malley, Theresa, et al.
Publicado: (2018)

Electrochemical Dehydrogenative C−H Aminomethylation of Imidazopyridines and Related Heterocycles
por: Huang, Raolin, et al.
Publicado: (2022)

Structure–Property Optimization of a Series of Imidazopyridines for Visceral Leishmaniasis
por: Dichiara, Maria, et al.
Publicado: (2023)

Synthesis and biological evaluation of novel thienopyrimidine derivatives as diacylglycerol acyltransferase 1 (DGAT-1) inhibitors
por: Hong, Dong Jin, et al.
Publicado: (2019)

Synthesis and Structure−Activity Relationships of Imidazopyridine/Pyrimidine‐ and Furopyridine‐Based Anti‐infective Agents against Trypanosomiases
por: Silva, Daniel G., et al.
Publicado: (2020)

Structure-Activity Relationship of Indole-Tethered Pyrimidine Derivatives that Concurrently Inhibit Epidermal Growth Factor Receptor and Other Angiokinases
por: Song, Jiho, et al.
Publicado: (2015)

Novel imidazopyridine suppresses STAT3 activation by targeting SHP-1
por: Su, Jung-Chen, et al.
Publicado: (2018)

Regioselective C3–H Alkylation of Imidazopyridines with Donor–Acceptor Cyclopropanes
por: Dalkilic, Oguzhan, et al.
Publicado: (2023)

Imidazopyridine Amides: Synthesis, Mycobacterium smegmatis CIII(2)CIV(2) Supercomplex Binding, and In Vitro Antimycobacterial Activity
por: Abdelaziz, Rana, et al.
Publicado: (2023)

Imidazopyridine-Based Thiazole Derivatives as Potential Antidiabetic Agents: Synthesis, In Vitro Bioactivity, and In Silico Molecular Modeling Approach
por: Hussain, Rafaqat, et al.
Publicado: (2023)

A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase PrkA
por: Schaenzer, Adam J., et al.
Publicado: (2017)

A Combined Pharmacophore Modeling, 3D QSAR and Virtual Screening Studies on Imidazopyridines as B-Raf Inhibitors
por: Xie, Huiding, et al.
Publicado: (2015)

Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines
por: Large, Jonathan M., et al.
Publicado: (2019)

Synthetic Imidazopyridine-Based Derivatives as Potential Inhibitors against Multi-Drug Resistant Bacterial Infections: A Review
por: Sanapalli, Bharat Kumar Reddy, et al.
Publicado: (2022)

TAK1 in brain endothelial cells mediates fever and lethargy
por: Ridder, Dirk A., et al.
Publicado: (2011)

Exogenous Addition of 25‐Hydroxycholesterol Reduces Level of Very Long‐Chain Fatty Acids in X‐Linked Adrenoleukodystrophy
por: Jang, Jiho, et al.
Publicado: (2019)

A One Pot Synthesis of Novel Bioactive Tri-Substitute-Condensed-Imidazopyridines that Targets Snake Venom Phospholipase A(2)
por: Anilkumar, Nirvanappa C., et al.
Publicado: (2015)

Toward more potent imidazopyridine inhibitors of Candida albicans Bdf1: Modeling the role of structural waters in selective ligand binding
por: Zhou, Yingsheng, et al.
Publicado: (2022)

Antimalarial Imidazopyridines Incorporating an Intramolecular Hydrogen Bonding Motif: Medicinal Chemistry and Mechanistic Studies
por: Attram, Henrietta D., et al.
Publicado: (2023)

Synthesis and biological activity of squaramido-tethered bisbenzimidazoles as synthetic anion transporters
por: Wang, Zhong-Kun, et al.
Publicado: (2021)

TAK1 Inhibitor Enhances the Therapeutic Treatment for Glioblastoma
por: Campolo, Michela, et al.
Publicado: (2020)

A Novel Imidazopyridine Derivative Exerts Anticancer Activity by Inducing Mitochondrial Pathway-Mediated Apoptosis
por: Wang, Juanli, et al.
Publicado: (2020)

Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy
por: Pan, Mengwu, et al.
Publicado: (2023)

TAK-981, a SUMOylation inhibitor, suppresses AML growth immune-independently
por: Kim, Han Sun, et al.
Publicado: (2023)

Design, synthesis, and biological evaluation of novel triazoloquinazolinone derivatives as SHP2 protein inhibitors
por: Luo, Rongshuang, et al.
Publicado: (2021)

Novel Imidazopyridine Derivatives Possess Anti-Tumor Effect on Human Castration-Resistant Prostate Cancer Cells
por: Ingersoll, Matthew A., et al.
Publicado: (2015)

Inhibition of inflammation and oxidative stress by an imidazopyridine derivative X22 prevents heart injury from obesity
por: Qian, Yuanyuan, et al.
Publicado: (2016)

Imidazopyridine-fused [1,3]diazepinones: modulations of positions 2 to 4 and their impacts on the anti-melanoma activity
por: Baccon-Sollier, Paul Le, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qhs7s3b6ga9togq2pkmndpvkeg