Effects of α subunit substitutions on the oxidation of βCys93 and the stability of sickle cell hemoglobin

The β subunit substitutions, F41Y and K82D, in sickle cell hemoglobin (Hb) (βE6 V) provides significant resistance to oxidative stress by shielding βCys93 from the oxidizing ferryl heme. We evaluated the oxidative resistance of βCys93 to hydrogen peroxide (H(2)O(2)) in α subunit mutations in βE6 V (...

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Detalles Bibliográficos
Autores principales: Hicks, Wayne, Meng, Fantao, Kassa, Tigist, Alayash, Abdu I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594797/
https://www.ncbi.nlm.nih.gov/pubmed/33059548
http://dx.doi.org/10.1080/13510002.2020.1834250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594797/
https://www.ncbi.nlm.nih.gov/pubmed/33059548
http://dx.doi.org/10.1080/13510002.2020.1834250

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