Multi-tissue epigenetic analysis of the osteoarthritis susceptibility locus mapping to the plectin gene PLEC

OBJECTIVE: In cartilage, the osteoarthritis (OA) associated single nucleotide polymorphism (SNP) rs11780978 correlates with differential expression of PLEC, and with differential methylation of PLEC CpG dinucleotides, forming eQTLs and mQTLs respectively. This implies that methylation links chondroc...

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Detalles Bibliográficos
Autores principales: Sorial, A.K., Hofer, I.M.J., Tselepi, M., Cheung, K., Parker, E., Deehan, D.J., Rice, S.J., Loughlin, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders For The Osteoarthritis Research Society 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594932/
https://www.ncbi.nlm.nih.gov/pubmed/32580029
http://dx.doi.org/10.1016/j.joca.2020.06.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594932/
https://www.ncbi.nlm.nih.gov/pubmed/32580029
http://dx.doi.org/10.1016/j.joca.2020.06.001

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