Conformational gating, dynamics and allostery in human monoacylglycerol lipase

Inhibition of human Monoacylglycerol Lipase (hMGL) offers a novel approach for treating neurological diseases. The design of inhibitors, targeting active-inactive conformational transitions of the enzyme, can be aided by understanding the interplay between structure and dynamics. Here, we report the...

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Detalles Bibliográficos
Autores principales: Tyukhtenko, Sergiy, Ma, Xiaoyu, Rajarshi, Girija, Karageorgos, Ioannis, Anderson, Kyle W., Hudgens, Jeffrey W., Guo, Jason J., Nasr, Mahmoud L., Zvonok, Nikolai, Vemuri, Kiran, Wagner, Gerhard, Makriyannis, Alexandros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595040/
https://www.ncbi.nlm.nih.gov/pubmed/33116203
http://dx.doi.org/10.1038/s41598-020-75497-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595040/
https://www.ncbi.nlm.nih.gov/pubmed/33116203
http://dx.doi.org/10.1038/s41598-020-75497-5

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