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Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells
Single-cell RNA sequencing studies on gene co-expression patterns could yield important regulatory and functional insights, but have so far been limited by the confounding effects of differentiation and cell cycle. We apply a tailored experimental design that eliminates these confounders, and report...
Autores principales: | Tarbier, Marcel, Mackowiak, Sebastian D., Frade, João, Catuara-Solarz, Silvina, Biryukova, Inna, Gelali, Eleni, Menéndez, Diego Bárcena, Zapata, Luis, Ossowski, Stephan, Bienko, Magda, Gallant, Caroline J., Friedländer, Marc R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595044/ https://www.ncbi.nlm.nih.gov/pubmed/33116115 http://dx.doi.org/10.1038/s41467-020-19011-5 |
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