Lipid droplet accumulating microglia represent a dysfunctional and pro-inflammatory state in the aging brain

Microglia become progressively activated and seemingly dysfunctional with age, and genetic studies have linked these cells to the pathogenesis of a growing number of neurodegenerative diseases. Here we report a striking buildup of lipid droplets in microglia with aging in mouse and human brains. The...

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Detalles Bibliográficos
Autores principales: Marschallinger, Julia, Iram, Tal, Zardeneta, Macy, Lee, Song E., Lehallier, Benoit, Haney, Michael S., Pluvinage, John V., Mathur, Vidhu, Hahn, Oliver, Morgens, David W., Kim, Justin, Tevini, Julia, Felder, Thomas K., Wolinski, Heimo, Bertozzi, Carolyn R., Bassik, Michael C., Aigner, Ludwig, Wyss-Coray, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595134/
https://www.ncbi.nlm.nih.gov/pubmed/31959936
http://dx.doi.org/10.1038/s41593-019-0566-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595134/
https://www.ncbi.nlm.nih.gov/pubmed/31959936
http://dx.doi.org/10.1038/s41593-019-0566-1

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