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Lipid droplet accumulating microglia represent a dysfunctional and pro-inflammatory state in the aging brain
Microglia become progressively activated and seemingly dysfunctional with age, and genetic studies have linked these cells to the pathogenesis of a growing number of neurodegenerative diseases. Here we report a striking buildup of lipid droplets in microglia with aging in mouse and human brains. The...
Autores principales: | Marschallinger, Julia, Iram, Tal, Zardeneta, Macy, Lee, Song E., Lehallier, Benoit, Haney, Michael S., Pluvinage, John V., Mathur, Vidhu, Hahn, Oliver, Morgens, David W., Kim, Justin, Tevini, Julia, Felder, Thomas K., Wolinski, Heimo, Bertozzi, Carolyn R., Bassik, Michael C., Aigner, Ludwig, Wyss-Coray, Tony |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595134/ https://www.ncbi.nlm.nih.gov/pubmed/31959936 http://dx.doi.org/10.1038/s41593-019-0566-1 |
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