Indole hydrazide compound ZJQ-24 inhibits angiogenesis and induces apoptosis cell death through abrogation of AKT/mTOR pathway in hepatocellular carcinoma

Angiogenesis and the activation of AKT/mTOR pathway are crucial for hepatocarcinoma development and progression, the activation of mTORC1/2 and relevant substrates have been confirmed in clinical hepatocarcinoma samples. Therefore, AKT/mTOR pathway represents the major targets for anti-cancer drugs...

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Detalles Bibliográficos
Autores principales: Liu, Jing, Liu, Ying, Zhang, Jianqiang, Liu, Dan, Bao, Yafeng, Chen, Tianxing, Tang, Tao, Lin, Jun, Luo, Ying, Jin, Yi, Zhang, Jihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595202/
https://www.ncbi.nlm.nih.gov/pubmed/33116125
http://dx.doi.org/10.1038/s41419-020-03108-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595202/
https://www.ncbi.nlm.nih.gov/pubmed/33116125
http://dx.doi.org/10.1038/s41419-020-03108-2

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