The Fuchs corneal dystrophy-associated CTG repeat expansion in the TCF4 gene affects transcription from its alternative promoters

The CTG trinucleotide repeat (TNR) expansion in Transcription factor 4 (TCF4) intron 3 is the main cause of Fuchs’ endothelial corneal dystrophy (FECD) and may confer an increased risk of developing bipolar disorder (BD). Usage of alternative 5′ exons for transcribing the human TCF4 gene results in...

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Detalles Bibliográficos
Autores principales: Sirp, Alex, Leite, Kristian, Tuvikene, Jürgen, Nurm, Kaja, Sepp, Mari, Timmusk, Tõnis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595208/
https://www.ncbi.nlm.nih.gov/pubmed/33116252
http://dx.doi.org/10.1038/s41598-020-75437-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595208/
https://www.ncbi.nlm.nih.gov/pubmed/33116252
http://dx.doi.org/10.1038/s41598-020-75437-3

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