Targeting of the E3 ubiquitin-protein ligase HUWE1 impairs DNA repair capacity and tumor growth in preclinical multiple myeloma models

Experimental evidence suggests that ubiquitin-protein ligases regulate a number of cellular processes involved in tumorigenesis. We analysed the role of the E3 ubiquitin-protein ligase HUWE1 for pathobiology of multiple myeloma (MM), a still incurable blood cancer. mRNA expression analysis indicates...

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Detalles Bibliográficos
Autores principales: Kunz, Viktoria, Bommert, Kathryn S., Kruk, Jessica, Schwinning, Daniel, Chatterjee, Manik, Stühmer, Thorsten, Bargou, Ralf, Bommert, Kurt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595222/
https://www.ncbi.nlm.nih.gov/pubmed/33116152
http://dx.doi.org/10.1038/s41598-020-75499-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595222/
https://www.ncbi.nlm.nih.gov/pubmed/33116152
http://dx.doi.org/10.1038/s41598-020-75499-3

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