Masking terminal neo-epitopes of linear peptides through glycosylation favours immune responses towards core epitopes producing parental protein bound antibodies

Glycosylation of hydrophobic peptides at one terminus effectively increases their water-solubility, and conjugation through the opposing end to a carrier protein, renders them more immunogenic. Moreover, the glycosylation minimizes antibody responses to potentially deleterious, non-productive termin...

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Detalles Bibliográficos
Autores principales: Pon, Robert, Marcil, Anne, Chen, Wangxue, Gadoury, Christine, Williams, Dean, Chan, Kenneth, Zhou, Hongyan, Ponce, Amalia, Paquet, Eric, Gurnani, Komal, Chattopadhyay, Anindita, Zou, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595224/
https://www.ncbi.nlm.nih.gov/pubmed/33116268
http://dx.doi.org/10.1038/s41598-020-75754-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595224/
https://www.ncbi.nlm.nih.gov/pubmed/33116268
http://dx.doi.org/10.1038/s41598-020-75754-7

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